4-Bromo-2-nitroanisole → 4-{4-Methoxy-2-[(5-methyl-thiophene-2-carbonyl)-amino]-benzothiazol-7-yl}-piperazine-1-carboxylic acid benzyl ester

HRID 939247Notes

Reaction equation

HRID 939247 reaction equation
[Br:17][c:18]1[cH:19][cH:20][c:21]([O:22][CH3:23])[c:24]([N+:25]([O-:26])=[O:27])[cH:28]1.[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH2:12][CH2:13][NH:14][CH2:15][CH2:16]1.[CH3:29][O:30][c:31]1[cH:32][cH:33][c:34]([N:49]2[CH2:50][CH2:51][O:52][CH2:53][CH2:54]2)[c:35]2[c:36]1[n:37][c:38]([NH:40][C:41](=[O:42])[c:43]1[s:44][c:45]([CH3:48])[cH:46][cH:47]1)[s:39]2>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9](=[O:10])[N:11]1[CH2:12][CH2:13][N:14]([c:34]2[cH:33][cH:32][c:31]([O:30][CH3:29])[c:36]3[c:35]2[s:39][c:38]([NH:40][C:41](=[O:42])[c:43]2[s:44][c:45]([CH3:48])[cH:46][cH:47]2)[n:37]3)[CH2:15][CH2:16]1

Participants

4

Reactant 3

HCID 1185334-Bromo-2-nitroanisoleHCID 643495Benzyl piperazine-1-carboxylateHCID 865849135-Methyl-thiophene-2-carboxylic acid (4-methoxy-7-morpholin-4-yl-benzothiazol-2-yl)-amide

Product 1

HCID 865849124-{4-Methoxy-2-[(5-methyl-thiophene-2-carbonyl)-amino]-benzothiazol-7-yl}-piperazine-1-carboxylic acid benzyl ester

Sources & evidence

ORD record
ord-a8c83c0b25204892bf4ca40c00081f6b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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