Methanol → 2-(4-(Azetidin-3-yl)piperazin-1-yl)pyrimidine

HRID 939314Notes

Reaction equation

HRID 939314 reaction equation
[CH3:37][OH:38].[CH3:39][CH2:40][O:41][CH2:42][CH3:43].[CH:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)([c:8]1[cH:9][cH:10][cH:11][cH:12][cH:13]1)[N:14]1[CH2:15][CH:16]([N:18]2[CH2:19][CH2:20][N:21]([c:24]3[n:25][cH:26][cH:27][cH:28][n:29]3)[CH2:22][CH2:23]2)[CH2:17]1.[Cl:30][C:31]([O:32][CH:33]([Cl:34])[CH3:35])=[O:36].[Cl:44][CH2:45][Cl:46]>>[NH:14]1[CH2:15][CH:16]([N:18]2[CH2:19][CH2:20][N:21]([c:24]3[n:25][cH:26][cH:27][cH:28][n:29]3)[CH2:22][CH2:23]2)[CH2:17]1

Participants

6

Reactant 5

HCID 887MethanolHCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 5213051-Chloroethyl chloroformateHCID 66770498HCID 66770498, compound

Product 1

HCID 534408612-(4-(Azetidin-3-yl)piperazin-1-yl)pyrimidine

Sources & evidence

ORD record
ord-182786b2d97b46fa9f03f5a79aa4c488
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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