5-chloro-2,4-difluoro-N-(methoxymethyl)-N-pyrimidin-4-ylbenzenesulfonamide → 5-chloro-4-(4-chloro-2-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenoxy)-2-fluoro-N-(methoxymethyl)-N-(pyrimidin-4-yl)benzenesulfonamide

HRID 939422Notes

Reaction equation

HRID 939422 reaction equation
[Cl:1][c:2]1[c:3]([F:22])[cH:4][c:5]([F:21])[c:6]([S:8](=[O:9])(=[O:10])[N:11]([c:12]2[n:13][cH:14][n:15][cH:16][cH:17]2)[CH2:18][O:19][CH3:20])[cH:7]1.[Cl:23][c:24]1[cH:25][c:26](-[c:31]2[c:32]([N+:42](=[O:43])[O-:44])[n:33][n:34]([CH:36]3[O:37][CH2:38][CH2:39][CH2:40][CH2:41]3)[cH:35]2)[c:27]([OH:30])[cH:28][cH:29]1>>[Cl:1][c:2]1[c:3]([O:30][c:27]2[c:26](-[c:31]3[c:32]([N+:42](=[O:43])[O-:44])[n:33][n:34]([CH:36]4[O:37][CH2:38][CH2:39][CH2:40][CH2:41]4)[cH:35]3)[cH:25][c:24]([Cl:23])[cH:29][cH:28]2)[cH:4][c:5]([F:21])[c:6]([S:8](=[O:9])(=[O:10])[N:11]([c:12]2[n:13][cH:14][n:15][cH:16][cH:17]2)[CH2:18][O:19][CH3:20])[cH:7]1

Participants

3

Reactant 2

HCID 594365115-chloro-2,4-difluoro-N-(methoxymethyl)-N-pyrimidin-4-ylbenzenesulfonamideHCID 594366304-chloro-2-[3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl]phenol

Product 1

HCID 594365105-chloro-4-(4-chloro-2-(3-nitro-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-4-yl)phenoxy)-2-fluoro-N-(methoxymethyl)-N-(pyrimidin-4-yl)benzenesulfonamide

Sources & evidence

ORD record
ord-4d493658758e45d2887faab4aa503d22
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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