Toluene → 4-Chloro-5-fluoro-2-methyl-quinolin-8-ol

HRID 939684Notes

Reaction equation

HRID 939684 reaction equation

[B:16]([Br:17])([Br:18])[Br:19].[CH3:20][c:21]1[cH:22][cH:23][cH:24][cH:25][cH:26]1.[Cl:1][c:2]1[cH:3][c:4]([CH3:15])[n:5][c:6]2[c:7]([O:13][CH3:14])[cH:8][cH:9][c:10]([F:12])[c:11]12.[Cl:27][CH2:28][Cl:29]>>[Cl:1][c:2]1[cH:3][c:4]([CH3:15])[n:5][c:6]2[c:7]([OH:13])[cH:8][cH:9][c:10]([F:12])[c:11]12

Participants

5

Reactant 4

HCID 1140Toluene

HCID 6344Dichloromethane

HCID 25134Boron tribromide

HCID 684232214-Chloro-5-fluoro-8-methoxy-2-methyl-quinoline

Product 1

HCID 670774504-Chloro-5-fluoro-2-methyl-quinolin-8-ol

Sources & evidence

ORD record: ord-1a6403b5298540cca27c2cf0fe209358
Source dataset: Validation data from https://doi.org/10.1039/C8SC04228D
DOI: 10.1039/C8SC04228D

Reaction notes

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