2-Methanesulfonylacetic acid → N-{2-[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]ethyl}-2-(methylsulfonyl)acetamide

HRID 939732Notes

Reaction equation

HRID 939732 reaction equation
[CH3:1][S:2](=[O:3])(=[O:4])[CH2:5][C:6](=[O:7])[OH:8].[NH2:9][CH2:10][CH2:11][O:12][c:13]1[c:14]2[c:15]([NH:23][c:24]3[cH:25][c:26]([Cl:38])[c:27]([O:30][CH2:31][c:32]4[n:33][cH:34][cH:35][cH:36][cH:37]4)[cH:28][cH:29]3)[n:16][cH:17][n:18][c:19]2[cH:20][cH:21][cH:22]1>>[CH3:1][S:2](=[O:3])(=[O:4])[CH2:5][C:6](=[O:8])[NH:9][CH2:10][CH2:11][O:12][c:13]1[c:14]2[c:15]([NH:23][c:24]3[cH:25][c:26]([Cl:38])[c:27]([O:30][CH2:31][c:32]4[n:33][cH:34][cH:35][cH:36][cH:37]4)[cH:28][cH:29]3)[n:16][cH:17][n:18][c:19]2[cH:20][cH:21][cH:22]1

Participants

3

Reactant 2

HCID 37328412-Methanesulfonylacetic acidHCID 690577145-(2-aminoethoxy)-N-[3-chloro-4-(pyridin-2-ylmethoxy)phenyl]quinazolin-4-amine

Product 1

HCID 11421373N-{2-[(4-{[3-Chloro-4-(pyridin-2-ylmethoxy)phenyl]amino}quinazolin-5-yl)oxy]ethyl}-2-(methylsulfonyl)acetamide

Sources & evidence

ORD record
ord-404e70167f9c4b898bd1d0cc07fc864e
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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