2-isobutyl-6-(2,4-difluorophenyl)-4-phthalimidomethyl-2H-pyridazin-3-one → 2-(4-chlorocinnamyl)-6-(4-fluoro-3-methylphenyl)-4-hydroxymethyl-2H-pyridazin-3-one
Reaction equation
[C:32](=[O:33])([OH:34])[c:35]1[c:36](=[O:59])[n:37]([CH2:49][CH:50]=[CH:51][c:52]2[cH:53][cH:54][c:55]([Cl:58])[cH:56][cH:57]2)[n:38][c:39](-[c:41]2[cH:42][c:43]([CH3:48])[c:44]([F:47])[cH:45][cH:46]2)[cH:40]1.[F:1][c:2]1[cH:3][c:4]([F:5])[cH:6][cH:7][c:8]1-[c:9]1[cH:10][c:11]([CH2:12][N:13]2[C:14](=[O:15])[c:16]3[cH:17][cH:18][cH:19][cH:20][c:21]3[C:22]2=[O:23])[c:24](=[O:25])[n:26]([CH2:27][CH:28]([CH3:29])[CH3:30])[n:31]1>>[CH2:32]([OH:33])[c:35]1[c:36](=[O:59])[n:37]([CH2:49][CH:50]=[CH:51][c:52]2[cH:53][cH:54][c:55]([Cl:58])[cH:56][cH:57]2)[n:38][c:39](-[c:41]2[cH:42][c:43]([CH3:48])[c:44]([F:47])[cH:45][cH:46]2)[cH:40]1Participants
3
Sources & evidence
- ORD record
- ord-068283bae91a4f80ac171a7b6ec9d55a
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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