6-(5,5-Dimethyl[1,3,2]dioxaborinan-2-yl)-2-fluorobenzonitrile → 5-(4-Fluorophenyl)-2-trifluoromethyl[1,8]naphthyridine

HRID 939835Notes

Reaction equation

HRID 939835 reaction equation
[CH3:30][C:31]1([CH3:32])[CH2:33][O:34][B:35]([c:36]2[c:37]([F:38])[c:39]([C:43]#[N:44])[cH:40][cH:41][cH:42]2)[O:45][CH2:46]1.[CH3:47][C:48]1([CH3:49])[CH2:50][O:51][B:52]([c:53]2[c:54]([C:55]#[N:56])[c:57]([F:58])[cH:59][cH:60][cH:61]2)[O:62][CH2:63]1.[F:1][c:2]1[c:3]([O:22][S:23]([C:24]([F:25])([F:26])[F:27])(=[O:28])=[O:29])[cH:4][c:5](-[c:8]2[cH:9][cH:10][n:11][c:12]3[n:13][c:14]([C:18]([F:19])([F:20])[F:21])[cH:15][cH:16][c:17]23)[cH:6][cH:7]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[cH:9][cH:10][n:11][c:12]3[n:13][c:14]([C:18]([F:19])([F:20])[F:21])[cH:15][cH:16][c:17]23)[cH:6][cH:7]1

Participants

4

Reactant 3

HCID 116802486-(5,5-Dimethyl[1,3,2]dioxaborinan-2-yl)-2-fluorobenzonitrileHCID 116943293-(5,5-Dimethyl[1,3,2]dioxaborinan-2-yl)-2-fluorobenzonitrileHCID 86594178Trifluoromethanesulfonic acid 2-fluoro-5-(7-trifluoromethyl[1,8]naphthyridin-4-yl)phenyl ester

Product 1

HCID 98791365-(4-Fluorophenyl)-2-trifluoromethyl[1,8]naphthyridine

Sources & evidence

ORD record
ord-d6185acd9276459492932886938beb87
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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