1-Butanol → 4-(p-Fluorobenzoyl)-1-(3-hydroxypropyl)piperidine
Reaction equation
[Br:16][CH2:17][CH2:18][CH2:19][OH:20].[C:21](=[O:22])([O-:23])[O-:24].[CH2:27]([OH:28])[CH2:29][CH2:30][CH3:31].[F:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[cH:14][cH:15]1.[K+:25].[K+:26]>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:6](=[O:7])[CH:8]2[CH2:9][CH2:10][N:11]([CH2:17][CH2:18][CH2:19][OH:20])[CH2:12][CH2:13]2)[cH:14][cH:15]1Participants
6
Sources & evidence
- ORD record
- ord-c77ed26f6e54436a9f5a7e1a6e8b064c
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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