5-Iodonicotinic acid → {2-Chloro-4-[5-[(5-iodo-pyridine-3-carbonyl)-amino]-2-(2,2,2-trifluoro-ethoxy)-pyridin-3-yl]-phenyl}-carbamic acid benzyl ester
Reaction equation
[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9]([NH:10][c:11]1[c:12]([Cl:30])[cH:13][c:14](-[c:17]2[c:18]([O:24][CH2:25][C:26]([F:27])([F:28])[F:29])[n:19][cH:20][c:21]([NH2:23])[cH:22]2)[cH:15][cH:16]1)=[O:31].[I:32][c:33]1[cH:34][c:35]([C:39](=[O:40])[OH:41])[cH:36][n:37][cH:38]1>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][C:9]([NH:10][c:11]1[c:12]([Cl:30])[cH:13][c:14](-[c:17]2[c:18]([O:24][CH2:25][C:26]([F:27])([F:28])[F:29])[n:19][cH:20][c:21]([NH:23][C:39]([c:35]3[cH:34][c:33]([I:32])[cH:38][n:37][cH:36]3)=[O:40])[cH:22]2)[cH:15][cH:16]1)=[O:31]Participants
3
Sources & evidence
- ORD record
- ord-55d69f2e9b454c148be3e6a1ac844d5a
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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