1-Butanol → 2-[1-[[6-amino-5-(trifluoromethyl)pyrimidin-4-yl]amino]ethyl]-3-cyclopropyl-N-methylbenzimidazole-4-carboxamide

HRID 940752Notes

Reaction equation

HRID 940752 reaction equation
[CH2:32]([OH:33])[CH2:34][CH2:35][CH3:36].[Cl:20][c:21]1[c:22]([C:28]([F:29])([F:30])[F:31])[c:23]([NH2:27])[n:24][cH:25][n:26]1.[NH2:1][CH:2]([CH3:3])[c:4]1[n:5][c:6]2[c:7]([n:8]1[CH:9]1[CH2:10][CH2:11]1)[c:12]([C:16](=[O:17])[NH:18][CH3:19])[cH:13][cH:14][cH:15]2>>[NH:1]([CH:2]([CH3:3])[c:4]1[n:5][c:6]2[c:7]([n:8]1[CH:9]1[CH2:10][CH2:11]1)[c:12]([C:16](=[O:17])[NH:18][CH3:19])[cH:13][cH:14][cH:15]2)[c:21]1[c:22]([C:28]([F:29])([F:30])[F:31])[c:23]([NH2:27])[n:24][cH:25][n:26]1

Participants

4

Reactant 3

HCID 2631-ButanolHCID 674335822-(1-aminoethyl)-3-cyclopropyl-N-methylbenzimidazole-4-carboxamideHCID 860496886-Chloro-5-(trifluoromethyl)pyrimidin-4-amine

Product 1

HCID 760444502-[1-[[6-amino-5-(trifluoromethyl)pyrimidin-4-yl]amino]ethyl]-3-cyclopropyl-N-methylbenzimidazole-4-carboxamide

Sources & evidence

ORD record
ord-21f36d7c8a5f4c7ab66717e20cc6cd89
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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