Acetone → 2-O-tert-butyl 1-O-methyl 6-[(3-chloro-2,6-difluorophenyl)methoxy]-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylate

HRID 940908Notes

Reaction equation

HRID 940908 reaction equation
[Br:23][CH2:24][c:25]1[c:26]([F:33])[cH:27][cH:28][c:29]([Cl:32])[c:30]1[F:31].[C:34](=[O:35])([O-:36])[O-:37].[CH3:40][C:41](=[O:42])[CH3:43].[Cs+:38].[Cs+:39].[OH:1][c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[CH:8]([C:12](=[O:13])[O:14][CH3:15])[N:7]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:6][CH2:5]2>>[O:1]([c:2]1[cH:3][c:4]2[c:9]([cH:10][cH:11]1)[CH:8]([C:12](=[O:13])[O:14][CH3:15])[N:7]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:6][CH2:5]2)[CH2:24][c:25]1[c:26]([F:33])[cH:27][cH:28][c:29]([Cl:32])[c:30]1[F:31]

Participants

6

Reactant 5

HCID 180AcetoneHCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 27735502-(Bromomethyl)-4-chloro-1,3-difluorobenzeneHCID 22888491HCID 22888491, compound

Product 1

HCID 685020772-O-tert-butyl 1-O-methyl 6-[(3-chloro-2,6-difluorophenyl)methoxy]-3,4-dihydro-1H-isoquinoline-1,2-dicarboxylate

Sources & evidence

ORD record
ord-a44e382ca1b24d1fb552139af778165b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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