2-(Methylsulfonyl)ethanamine → 2,6-Difluoro-N-{3-[5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

HRID 941102Notes

Reaction equation

HRID 941102 reaction equation
[Cl:8][c:9]1[n:10][cH:11][cH:12][c:13](-[c:15]2[c:16](-[c:25]3[cH:26][c:27]([NH:31][S:32](=[O:33])(=[O:34])[c:35]4[c:36]([F:42])[cH:37][cH:38][cH:39][c:40]4[F:41])[cH:28][cH:29][cH:30]3)[n:17][c:18]([N:20]3[CH2:21][CH2:22][CH2:23][CH2:24]3)[s:19]2)[n:14]1.[NH2:1][CH2:2][CH2:3][S:4](=[O:5])(=[O:6])[CH3:7]>>[NH:1]([CH2:2][CH2:3][S:4](=[O:5])(=[O:6])[CH3:7])[c:9]1[n:10][cH:11][cH:12][c:13](-[c:15]2[c:16](-[c:25]3[cH:26][c:27]([NH:31][S:32](=[O:33])(=[O:34])[c:35]4[c:36]([F:42])[cH:37][cH:38][cH:39][c:40]4[F:41])[cH:28][cH:29][cH:30]3)[n:17][c:18]([N:20]3[CH2:21][CH2:22][CH2:23][CH2:24]3)[s:19]2)[n:14]1

Participants

3

Reactant 2

HCID 43405612-(Methylsulfonyl)ethanamineHCID 57989807N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}-2,6-difluorobenzenesulfonamide

Product 1

HCID 579896542,6-Difluoro-N-{3-[5-(2-{[2-(methylsulfonyl)ethyl]amino}-4-pyrimidinyl)-2-(1-pyrrolidinyl)-1,3-thiazol-4-yl]phenyl}benzenesulfonamide

Sources & evidence

ORD record
ord-c2ed9ec7520641e0b07d8e4d82767df8
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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