1-[2-Fluoro-4-(methylsulfonyl)phenyl]piperazine → (2,6-Difluoro-3-methanesulfonyl-phenyl)-[4-(2-fluoro-4-methanesulfonyl-phenyl)-piperazin-1-yl]-methanone
Reaction equation
[F:18][c:19]1[c:20]([C:21](=[O:22])[OH:23])[c:24]([F:32])[cH:25][cH:26][c:27]1[S:28](=[O:29])(=[O:30])[CH3:31].[F:1][c:2]1[c:3]([N:12]2[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]2)[cH:4][cH:5][c:6]([S:8](=[O:9])(=[O:10])[CH3:11])[cH:7]1>>[F:1][c:2]1[c:3]([N:12]2[CH2:13][CH2:14][N:15]([C:21]([c:20]3[c:19]([F:18])[c:27]([S:28](=[O:29])(=[O:30])[CH3:31])[cH:26][cH:25][c:24]3[F:32])=[O:22])[CH2:16][CH2:17]2)[cH:4][cH:5][c:6]([S:8](=[O:9])(=[O:10])[CH3:11])[cH:7]1Participants
3
Sources & evidence
- ORD record
- ord-ccf7e8dd1bfc4b78bfcb3062f849cbc1
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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