Pyridine → Diethyl 2-methyl-4-(2-nitrophenyl)-6-acetoxymethyl-1,4-dihydropyridine-3,5-dicarboxylate

HRID 941189Notes

Reaction equation

HRID 941189 reaction equation
[CH2:44]([Cl:45])[Cl:46].[CH3:1][C:2]1=[C:7]([C:8](=[O:9])[O:10][CH2:11][CH3:12])[CH:6]([c:13]2[c:14]([N+:19](=[O:20])[O-:21])[cH:15][cH:16][cH:17][cH:18]2)[C:5]([C:22](=[O:23])[O:24][CH2:25][CH3:26])=[C:4]([CH2:27][OH:28])[NH:3]1.[CH3:29][C:30]([Cl:31])=[O:32].[CH3:33][CH2:34][O:35][CH2:36][CH3:37].[cH:38]1[cH:39][cH:40][n:41][cH:42][cH:43]1>>[CH3:1][C:2]1=[C:7]([C:8](=[O:9])[O:10][CH2:11][CH3:12])[CH:6]([c:13]2[c:14]([N+:19](=[O:20])[O-:21])[cH:15][cH:16][cH:17][cH:18]2)[C:5]([C:22](=[O:23])[O:24][CH2:25][CH3:26])=[C:4]([CH2:27][O:28][C:30]([CH3:29])=[O:32])[NH:3]1

Participants

6

Reactant 5

HCID 1049PyridineHCID 3283Diethyl EtherHCID 6344DichloromethaneHCID 6367Acetyl chlorideHCID 133883402-Hydroxymethyl-6-methyl-4-(nitrophenyl)-3,5-diethoxycarbonyl-1,4-dihydropyridine

Product 1

HCID 13388345Diethyl 2-methyl-4-(2-nitrophenyl)-6-acetoxymethyl-1,4-dihydropyridine-3,5-dicarboxylate

Sources & evidence

ORD record
ord-5b5bdb5e31c74f6ab9d649b4db61d73d
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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