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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 941371Generated: October 25, 2026

Toluene → 2-[(Tert-butyl-dimethyl-silanyloxy)-cyclohexyl-methyl]-4-(2-chloro-ethyl)-3-methylene-5-oxo-pyrrolidine-2-carboxylic acid methyl ester

https://huagongshe.com/reaction/941371

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTolueneHCID 1140—
ReactantChlorotrimethylsilaneHCID 6397—
ReactantTetrahydrofuranHCID 8028—
ReactantLithium ionHCID 28486—
Reactant2-Chloroethyl trifluoromethanesulfonateHCID 100525—
ReactantDiisopropylamideHCID 5062348—
Reactant2-[(tert-butyl-dimethyl-silanyloxy)-cyclohexyl-methyl]-3-methyl-5-oxo-2,5-dihydro-1H-pyrrole-2-carboxylic acid methyl esterHCID 68576277—
Product2-[(Tert-butyl-dimethyl-silanyloxy)-cyclohexyl-methyl]-4-(2-chloro-ethyl)-3-methylene-5-oxo-pyrrolidine-2-carboxylic acid methyl esterHCID 68577346—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-87bc15b1360f472290bfc99f74539d4a
Source noteValidation data from https://doi.org/10.1039/C8SC04228D