Dimethyl Sulfoxide → 1-chloro-4-(octahydroisoquinolin-2(1H)-yl)phthalazine

HRID 941539Notes

Reaction equation

HRID 941539 reaction equation
[C:23](=[O:24])([O-:25])[O-:26].[CH2:13]1[NH:14][CH2:15][CH2:16][CH:17]2[CH2:18][CH2:19][CH2:20][CH2:21][CH:22]12.[CH3:29][S:30]([CH3:31])=[O:32].[Cl:1][c:2]1[n:3][n:4][c:5]([Cl:12])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[K+:27].[K+:28]>>[c:2]1([N:14]2[CH2:13][CH:22]3[CH:17]([CH2:16][CH2:15]2)[CH2:18][CH2:19][CH2:20][CH2:21]3)[n:3][n:4][c:5]([Cl:12])[c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 784901,4-DichlorophthalazineHCID 97812Decahydroisoquinoline

Product 1

HCID 594273491-chloro-4-(octahydroisoquinolin-2(1H)-yl)phthalazine

Sources & evidence

ORD record
ord-c1860b8ed001459494cc29838717c99f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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