6-Morpholin-4-ylpyridazine-3-carboxylic acid → N-[(3RS,4SR)-4-(3,4-dichloro-phenyl)-1-(6-morpholin-4-yl-pyridazine-3-carbonyl)-pyrrolidin-3-yl]-2-(4-fluoro-phenyl)-N-methyl-acetamide
Reaction equation
[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH:10]([N:14]([C:15]([CH2:16][c:17]3[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]3)=[O:24])[CH3:25])[CH2:11][NH:12][CH2:13]2)[cH:5][cH:6][c:7]1[Cl:8].[O:26]1[CH2:27][CH2:28][N:29]([c:32]2[cH:33][cH:34][c:35]([C:38](=[O:39])[OH:40])[n:36][n:37]2)[CH2:30][CH2:31]1>>[Cl:1][c:2]1[cH:3][c:4]([CH:9]2[CH:10]([N:14]([C:15]([CH2:16][c:17]3[cH:18][cH:19][c:20]([F:23])[cH:21][cH:22]3)=[O:24])[CH3:25])[CH2:11][N:12]([C:38]([c:35]3[cH:34][cH:33][c:32]([N:29]4[CH2:28][CH2:27][O:26][CH2:31][CH2:30]4)[n:37][n:36]3)=[O:39])[CH2:13]2)[cH:5][cH:6][c:7]1[Cl:8]Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-3521d00860534ee2b357d6ce89ce33d3
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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