Acetic Acid → 4-[4-(4-Fluorophenyl)-1-pyrrolidin-3-yl-1H-imidazol-5-yl]pyrimidine

HRID 941594Notes

Reaction equation

HRID 941594 reaction equation
[C:62]([OH:63])(=[O:64])[CH3:65].[CH:66]([NH2:67])=[NH:68].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][cH:10][n:11]([CH:19]3[CH2:20][N:21]([C:24]([O:25][C:26]([CH3:27])([CH3:28])[CH3:29])=[O:30])[CH2:22][CH2:23]3)[c:12]2-[c:13]2[n:14][cH:15][n:16][cH:17][cH:18]2)[cH:6][cH:7]1.[F:69][c:70]1[cH:71][cH:72][c:73](-[c:74]2[n:75][cH:76][n:77]([CH:78]3[CH2:79][CH2:80][NH:81][CH2:82]3)[c:83]2-[c:84]2[cH:85][cH:86][n:87][c:88]([NH2:89])[n:90]2)[cH:91][cH:92]1.[NH2:31][c:32]1[n:33][c:34](-[c:35]2[n:36]([CH:37]3[CH2:38][CH2:39][N:40]([C:41]([O:42][C:43]([CH3:44])([CH3:45])[CH3:46])=[O:47])[CH2:48]3)[cH:49][n:50][c:51]2-[c:52]2[cH:53][cH:54][c:55]([F:56])[cH:57][cH:58]2)[cH:59][cH:60][n:61]1>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[n:9][cH:10][n:11]([CH:19]3[CH2:20][NH:21][CH2:22][CH2:23]3)[c:12]2-[c:13]2[n:14][cH:15][n:16][cH:17][cH:18]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 176Acetic AcidHCID 68047FormamidineHCID 57461720HCID 57461720, compoundHCID 57461721HCID 57461721, compoundHCID 57461722tert-Butyl 3-[4-(4-fluorophenyl)-5-pyrimidin-4-yl-1H-imidazol-1-yl]pyrrolidine-1-carboxylate

Product 1

HCID 574617254-[4-(4-Fluorophenyl)-1-pyrrolidin-3-yl-1H-imidazol-5-yl]pyrimidine

Sources & evidence

ORD record
ord-bef27f7f9a6a4a0aaa62483fc0fad11f
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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