Methanol → Ethyl 1-(4-amino-3-(2,2,2-trifluoroethoxy)phenyl)cyclobutanecarboxylate

HRID 941815Notes

Reaction equation

HRID 941815 reaction equation
[CH3:25][OH:26].[N+:1]([O-:2])(=[O:3])[c:4]1[c:5]([O:19][CH2:20][C:21]([F:22])([F:23])[F:24])[cH:6][c:7]([C:10]2([C:14](=[O:15])[O:16][CH2:17][CH3:18])[CH2:11][CH2:12][CH2:13]2)[cH:8][cH:9]1.[OH-:27].[OH-:28].[Pd+2:29]>>[NH2:1][c:4]1[c:5]([O:19][CH2:20][C:21]([F:22])([F:23])[F:24])[cH:6][c:7]([C:10]2([C:14](=[O:15])[O:16][CH2:17][CH3:18])[CH2:11][CH2:12][CH2:13]2)[cH:8][cH:9]1

Participants

5

Reactant 4

HCID 887MethanolHCID 961Hydroxide2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 57995578Ethyl 1-(4-nitro-3-(2,2,2-trifluoroethoxy)phenyl)cyclobutanecarboxylate

Product 1

HCID 57995647Ethyl 1-(4-amino-3-(2,2,2-trifluoroethoxy)phenyl)cyclobutanecarboxylate

Sources & evidence

ORD record
ord-1de88323fc5f4bceb1016577ef25c676
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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