Dimethyl Sulfoxide → 1-[4-(2-Fluorophenylmethyl)amino-2-methyl-3-quinolinyl]-ethanone

HRID 941913Notes

Reaction equation

HRID 941913 reaction equation
[CH3:27][S:28]([CH3:29])=[O:30].[F:18][c:19]1[c:20]([CH2:21][Cl:22])[cH:23][cH:24][cH:25][cH:26]1.[K+:17].[NH2:1][c:2]1[c:3]([C:13]([CH3:14])=[O:15])[c:4]([CH3:12])[n:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12.[OH-:16].[OH2:31]>>[NH:1]([c:2]1[c:3]([C:13]([CH3:14])=[O:15])[c:4]([CH3:12])[n:5][c:6]2[cH:7][cH:8][cH:9][cH:10][c:11]12)[CH2:21][c:20]1[c:19]([F:18])[cH:26][cH:25][cH:24][cH:23]1

Participants

7

Reactant 6

HCID 679Dimethyl SulfoxideHCID 813Potassium CationHCID 961HydroxideHCID 962WaterHCID 9580Benzene, 1-(chloromethyl)-2-fluoro-HCID 6722971-(4-Amino-2-methylquinolin-3-yl)ethanone

Product 1

HCID 143906181-[4-(2-Fluorophenylmethyl)amino-2-methyl-3-quinolinyl]-ethanone

Sources & evidence

ORD record
ord-82d3ce4750bf49d1afc576300d53ffdf
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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