Acetate → 7-(2-fluoro-4-nitrophenoxy)-N-(3-methoxyphenyl)thieno[3,2-b]pyridin-2-amine

HRID 942283Notes

Reaction equation

HRID 942283 reaction equation
[C:22](=[O:23])([O-:24])[O-:25].[CH3:28][O:29][c:30]1[cH:31][c:32]([NH2:33])[cH:34][cH:35][cH:36]1.[Cs+:26].[Cs+:27].[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12]([I:14])[s:13]3)[cH:15][cH:16][c:17]([N+:19](=[O:20])[O-:21])[cH:18]1.[O-:44][C:45]([CH3:46])=[O:47].[O-:48][C:49]([CH3:50])=[O:51].[O:37]1[CH2:38][CH2:39][O:40][CH2:41][CH2:42]1.[Pd+2:43]>>[F:1][c:2]1[c:3]([O:4][c:5]2[c:6]3[c:7]([n:8][cH:9][cH:10]2)[cH:11][c:12]([NH:33][c:32]2[cH:31][c:30]([O:29][CH3:28])[cH:36][cH:35][cH:34]2)[s:13]3)[cH:15][cH:16][c:17]([N+:19](=[O:20])[O-:21])[cH:18]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 108243-MethoxyanilineHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 104967Cesium cation2×HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 594576617-(2-Fluoro-4-nitrophenoxy)-2-iodothieno[3,2-b]pyridine

Product 1

HCID 594576847-(2-fluoro-4-nitrophenoxy)-N-(3-methoxyphenyl)thieno[3,2-b]pyridin-2-amine

Sources & evidence

ORD record
ord-67709d9ab6664c6a93a4dcc1387d16df
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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