Acetic Acid → tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate

HRID 942377Notes

Reaction equation

HRID 942377 reaction equation
[C:27]([BH3-:28])#[N:29].[CH3:23][C:24](=[O:25])[OH:26].[CH3:33][OH:34].[NH2:1][c:2]1[cH:3][cH:4][cH:5][c:6]([F:7])[cH:8]1.[Na+:30].[Na+:32].[O:9]=[C:10]1[CH2:11][CH2:12][N:13]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:14][CH2:15]1.[OH-:31]>>[NH:1]([c:2]1[cH:3][cH:4][cH:5][c:6]([F:7])[cH:8]1)[CH:10]1[CH2:11][CH2:12][N:13]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:14][CH2:15]1

Participants

8

Reactant 7

HCID 176Acetic AcidHCID 887MethanolHCID 923Sodium ion2×HCID 961HydroxideHCID 97423-FluoroanilineHCID 498716Cyano-borohydrideHCID 735900tert-Butyl 4-oxopiperidine-1-carboxylate

Product 1

HCID 23137591tert-Butyl 4-(3-fluoroanilino)piperidine-1-carboxylate

Sources & evidence

ORD record
ord-7c7c5ffc72d34b59827a4b33124db604
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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