Acetonitrile → Methyl 6-(2-chloro-4-[(2-furanylmethyl)amino]-5-(2,2,2-trichloroethoxycarbonyl)phenylsulfonamidomethoxy)(6-oxo)hexanoate

HRID 942452Notes

Reaction equation

HRID 942452 reaction equation
[CH2:40]1[CH2:41][N:42]2[C:43](=[N:47][CH2:48]1)[CH2:44][CH2:45][CH2:46]2.[CH3:27][O:28][C:29]([CH2:30][CH2:31][CH2:32][CH2:33][C:34](=[O:35])[O:36][CH2:37][Cl:38])=[O:39].[CH3:49][C:50]#[N:51].[Cl:52][CH2:53][Cl:54].[NH2:1][S:2](=[O:3])(=[O:4])[c:5]1[c:6]([Cl:26])[cH:7][c:8]([NH:19][CH2:20][c:21]2[o:22][cH:23][cH:24][cH:25]2)[c:9]([C:10](=[O:11])[O:12][CH2:13][C:14]([Cl:15])([Cl:16])[Cl:17])[cH:18]1>>[NH:1]([S:2](=[O:3])(=[O:4])[c:5]1[c:6]([Cl:26])[cH:7][c:8]([NH:19][CH2:20][c:21]2[o:22][cH:23][cH:24][cH:25]2)[c:9]([C:10](=[O:11])[O:12][CH2:13][C:14]([Cl:15])([Cl:16])[Cl:17])[cH:18]1)[CH2:37][O:36][C:34]([CH2:33][CH2:32][CH2:31][CH2:30][C:29]([O:28][CH3:27])=[O:39])=[O:35]

Participants

6

Reactant 5

HCID 6342AcetonitrileHCID 6344DichloromethaneHCID 763491,5-Diazabicyclo(4.3.0)non-5-eneHCID 19611278Chloromethyl 6-methoxy-6-oxohexanoateHCID 593891212,2,2-Trichloroethyl 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino]benzoate

Product 1

HCID 68453359Methyl 6-(2-chloro-4-[(2-furanylmethyl)amino]-5-(2,2,2-trichloroethoxycarbonyl)phenylsulfonamidomethoxy)(6-oxo)hexanoate

Sources & evidence

ORD record
ord-de02b3d13aeb4bcb9eb9f97f10d6fe6d
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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