5-Chloro-2-(3,5-dimethylpiperazin-1-yl)quinoline → 9-[4-[4-(5-chloroquinolin-2-yl)-2,6-dimethylpiperazin-1-yl]butyl]-N-[(4-fluorophenyl)methyl]fluorene-9-carboxamide

HRID 94246Notes

Reaction equation

HRID 94246 reaction equation
[Cl:30][c:31]1[c:32]2[cH:33][cH:34][c:35]([N:41]3[CH2:42][CH:43]([CH3:48])[NH:44][CH:45]([CH3:47])[CH2:46]3)[n:36][c:37]2[cH:38][cH:39][cH:40]1.[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][NH:7][C:8](=[O:9])[C:10]2([CH2:23][CH2:24][CH2:25][CH2:26][Br:27])[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3-[c:17]3[cH:18][cH:19][cH:20][cH:21][c:22]32)[cH:28][cH:29]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([CH2:6][NH:7][C:8](=[O:9])[C:10]2([CH2:23][CH2:24][CH2:25][CH2:26][N:44]3[CH:43]([CH3:48])[CH2:42][N:41]([c:35]4[cH:34][cH:33][c:32]5[c:31]([Cl:30])[cH:40][cH:39][cH:38][c:37]5[n:36]4)[CH2:46][CH:45]3[CH3:47])[c:11]3[cH:12][cH:13][cH:14][cH:15][c:16]3-[c:17]3[cH:18][cH:19][cH:20][cH:21][c:22]32)[cH:28][cH:29]1

Participants

3

Reactant 2

HCID 226361845-Chloro-2-(3,5-dimethylpiperazin-1-yl)quinolineHCID 226362389-(4-bromo-butyl)-9H-fluorene-9-carboxylic acid-4-fluoro-benzylamide

Product 1

HCID 1784298669-[4-[4-(5-chloroquinolin-2-yl)-2,6-dimethylpiperazin-1-yl]butyl]-N-[(4-fluorophenyl)methyl]fluorene-9-carboxamide

Sources & evidence

ORD record
ord-771c785df5dd46788f6c40b5016eb621
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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