(2-Chloro-5-fluoropyrimidin-4-yl)-(3,4-dichlorophenyl)amine → (+/-)-N4-(3,4-dichlorophenyl)-N2-(2,3-dihydro-2-methoxycarbonylbenzofuran-5-yl)-5-fluoro-2,4-pyrimidinediamine

HRID 942595Notes

Reaction equation

HRID 942595 reaction equation
[Cl:15][c:16]1[n:17][cH:18][c:19]([F:31])[c:20]([NH:22][c:23]2[cH:24][c:25]([Cl:30])[c:26]([Cl:29])[cH:27][cH:28]2)[n:21]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:14]1)[CH2:7][CH:8]([C:10](=[O:11])[O:12][CH3:13])[O:9]2>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:14]1)[CH2:7][CH:8]([C:10](=[O:11])[O:12][CH3:13])[O:9]2)[c:16]1[n:17][cH:18][c:19]([F:31])[c:20]([NH:22][c:23]2[cH:24][c:25]([Cl:30])[c:26]([Cl:29])[cH:27][cH:28]2)[n:21]1

Participants

3

Reactant 2

HCID 22060411(2-Chloro-5-fluoropyrimidin-4-yl)-(3,4-dichlorophenyl)amineHCID 22060823Methyl 5-amino-2,3-dihydrobenzofuran-2-carboxylate

Product 1

HCID 10310474(+/-)-N4-(3,4-dichlorophenyl)-N2-(2,3-dihydro-2-methoxycarbonylbenzofuran-5-yl)-5-fluoro-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-d421696bc35a400e895c421b0506f153
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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