2-(Chloromethyl)-1,3-thiazole → N-[2-[4-[3-methyl-4-(1,3-thiazol-2-ylmethoxy)anilino]quinazolin-5-yl]oxypropyl]acetamide
Reaction equation
[Cl:1][CH2:2][c:3]1[s:4][cH:5][cH:6][n:7]1.[OH:8][c:9]1[c:10]([CH3:34])[cH:11][c:12]([NH:15][c:16]2[n:17][cH:18][n:19][c:20]3[cH:21][cH:22][cH:23][c:24]([O:26][CH:27]([CH2:28][NH:29][C:30]([CH3:31])=[O:32])[CH3:33])[c:25]23)[cH:13][cH:14]1>>[CH2:2]([c:3]1[s:4][cH:5][cH:6][n:7]1)[O:8][c:9]1[c:10]([CH3:34])[cH:11][c:12]([NH:15][c:16]2[n:17][cH:18][n:19][c:20]3[cH:21][cH:22][cH:23][c:24]([O:26][CH:27]([CH2:28][NH:29][C:30]([CH3:31])=[O:32])[CH3:33])[c:25]23)[cH:13][cH:14]1Participants
3
Sources & evidence
- ORD record
- ord-273723f8c8434f6c8770146c05293874
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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