2-Chloro-4-(2-(trimethylsilyl)ethynyl)pyridine → 5-[4-(2-Chloro-pyridin-4-ylethynyl)-2,5-dimethyl-imidazol-1-yl]-2-(2-methoxy-ethyl)-2H-pyridazin-3-one
Reaction equation
[Cl:20][c:21]1[n:22][cH:23][cH:24][c:25]([C:27]#[C:28][Si:29]([CH3:30])([CH3:31])[CH3:32])[cH:26]1.[I:1][c:2]1[n:3][c:4]([CH3:19])[n:5](-[c:8]2[cH:9][c:10](=[O:18])[n:11]([CH2:14][CH2:15][O:16][CH3:17])[n:12][cH:13]2)[c:6]1[CH3:7]>>[c:2]1([C:28]#[C:27][c:25]2[cH:24][cH:23][n:22][c:21]([Cl:20])[cH:26]2)[n:3][c:4]([CH3:19])[n:5](-[c:8]2[cH:9][c:10](=[O:18])[n:11]([CH2:14][CH2:15][O:16][CH3:17])[n:12][cH:13]2)[c:6]1[CH3:7]Participants
3
Sources & evidence
- ORD record
- ord-0beefef1d69c4f269a0a2e2ad159bfe5
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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