Potassium Cation → 1-[2-(3,4-Dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(4-hydroxy-3-methoxyphenyl)piperidine

HRID 943846Notes

Reaction equation

HRID 943846 reaction equation
[Br:16][CH2:17][CH2:18][CH:19]1[CH2:20][CH2:21][O:22][c:23]2[c:24]1[cH:25][cH:26][cH:27][cH:28]2.[CH3:31][C:32](=[O:33])[CH2:34][CH3:35].[I-:30].[K+:29].[OH:1][c:2]1[c:3]([O:14][CH3:15])[cH:4][c:5]([CH:8]2[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]2)[cH:6][cH:7]1>>[OH:1][c:2]1[c:3]([O:14][CH3:15])[cH:4][c:5]([CH:8]2[CH2:9][CH2:10][N:11]([CH2:17][CH2:18][CH:19]3[CH2:20][CH2:21][O:22][c:23]4[c:24]3[cH:25][cH:26][cH:27][cH:28]4)[CH2:12][CH2:13]2)[cH:6][cH:7]1

Participants

6

Reactant 5

HCID 813Potassium CationHCID 6569Methyl Ethyl KetoneHCID 30165Iodide IonHCID 143302824-(2-bromoethyl)-3,4-dihydro-2H-benzopyranHCID 221542522-Methoxy-4-(piperidin-4-yl)phenol

Product 1

HCID 221542261-[2-(3,4-Dihydro-1(2H)-benzopyran-4-yl)ethyl]-4-(4-hydroxy-3-methoxyphenyl)piperidine

Sources & evidence

ORD record
ord-2bc494a872ab4032b6f2fa5514cd716b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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