1-Methyl-3-aminopyrazole → 4-[2,2-Dimethyl-6-(1-methyl-1H-pyrazol-3-ylcarbamoyl)-2,3-dihydro-benzofuran-4-yloxy]-2-fluoro-benzoic acid tert-butyl ester

HRID 943878Notes

Reaction equation

HRID 943878 reaction equation
[C:8]([CH3:9])([CH3:10])([CH3:11])[O:12][C:13](=[O:14])[c:15]1[c:16]([F:36])[cH:17][c:18]([O:19][c:20]2[cH:21][c:22]([C:31](=[O:32])[OH:33])[cH:23][c:24]3[c:25]2[CH2:26][C:27]([CH3:29])([CH3:30])[O:28]3)[cH:34][cH:35]1.[CH3:1][n:2]1[n:3][c:4]([NH2:7])[cH:5][cH:6]1>>[CH3:1][n:2]1[n:3][c:4]([NH:7][C:31]([c:22]2[cH:21][c:20]([O:19][c:18]3[cH:17][c:16]([F:36])[c:15]([C:13]([O:12][C:8]([CH3:9])([CH3:10])[CH3:11])=[O:14])[cH:35][cH:34]3)[c:25]3[c:24]([cH:23]2)[O:28][C:27]([CH3:29])([CH3:30])[CH2:26]3)=[O:32])[cH:5][cH:6]1

Participants

3

Reactant 2

HCID 1372541-Methyl-3-aminopyrazoleHCID 595599864-(4-tert-Butoxycarbonyl-3-fluoro-phenoxy)-2,2-dimethyl-2,3-dihydro-benzofuran-6-carboxylic acid

Product 1

HCID 595600544-[2,2-Dimethyl-6-(1-methyl-1H-pyrazol-3-ylcarbamoyl)-2,3-dihydro-benzofuran-4-yloxy]-2-fluoro-benzoic acid tert-butyl ester

Sources & evidence

ORD record
ord-3c9b7d428b92428fba08841da5554cb9
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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