Carbonate Ion → N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)quinolin-4-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide

HRID 943993Notes

Reaction equation

HRID 943993 reaction equation
[C:51](=[O:52])([O-:53])[O-:54].[CH3:35][S:36]([O:37][CH2:40][CH2:41][CH2:42][N:43]1[CH2:44][C:45]2([CH2:46][CH2:47]2)[CH:48]([OH:50])[CH2:49]1)(=[O:38])=[O:39].[Cs+:55].[Cs+:56].[F:1][c:2]1[cH:3][c:4]([N:20]([C:21](=[O:22])[C:23]2([C:26](=[O:27])[NH2:28])[CH2:24][CH2:25]2)[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:5][cH:6][c:7]1[O:8][c:9]1[cH:10][cH:11][n:12][c:13]2[cH:14][c:15]([OH:19])[cH:16][cH:17][c:18]12>>[F:1][c:2]1[cH:3][c:4]([N:20]([C:21](=[O:22])[C:23]2([C:26](=[O:27])[NH2:28])[CH2:24][CH2:25]2)[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:5][cH:6][c:7]1[O:8][c:9]1[cH:10][cH:11][n:12][c:13]2[cH:14][c:15]([O:19][CH2:40][CH2:41][CH2:42][N:43]3[CH2:44][C:45]4([CH2:46][CH2:47]4)[CH:48]([OH:50])[CH2:49]3)[cH:16][cH:17][c:18]12

Participants

5

Reactant 4

HCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 86640798HCID 86640798, compoundHCID 136347992N-(3-fluoro-4-(7-hydroxyquinolin-4-yloxy)phenyl)-N-phenylcyclopropane-1,1-dicarboxamide

Product 1

HCID 68635307N-(4-(7-(3-(7-hydroxy-5-azaspiro[2.4]heptane-5-yl)propoxy)quinolin-4-yloxy)-3-fluorophenyl)-N-phenylcyclopropane-1,1-dicarboxamide

Sources & evidence

ORD record
ord-5096bf3a78c64b92a4609bf0e7e6925c
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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