N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanol → 2-(2-chloro-6-fluorophenyl)-4-phenyl-5,6-dihydro(4H)1,3-oxazine

HRID 944008Notes

Reaction equation

HRID 944008 reaction equation
[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][CH:7]([CH2:8][CH2:9][OH:10])[c:11]2[cH:12][cH:13][cH:14][cH:15][cH:16]2)[c:17]([F:21])[cH:18][cH:19][cH:20]1.[F:22][c:23]1[cH:24][cH:25][cH:26][c:27]([F:28])[c:29]1[C:30]([NH:31][CH:32]([c:33]1[cH:34][cH:35][c:36]([Cl:37])[cH:38][cH:39]1)[CH2:40][CH2:41][OH:42])=[O:43]>>[Cl:1][c:2]1[c:3]([C:4]2=[N:6][CH:7]([c:11]3[cH:12][cH:13][cH:14][cH:15][cH:16]3)[CH2:8][CH2:9][O:10]2)[c:17]([F:21])[cH:18][cH:19][cH:20]1

Participants

3

Reactant 2

HCID 15790732N-(2,6-difluorobenzoyl)-3-amino-3-(4-chlorophenyl) 1-propanolHCID 22115251N-(2-chloro-6-fluorobenzoyl)-3-amino-3-phenyl-1-propanol

Product 1

HCID 221152542-(2-chloro-6-fluorophenyl)-4-phenyl-5,6-dihydro(4H)1,3-oxazine

Sources & evidence

ORD record
ord-66d87c2048e547c69344d5e7a6a7cf69
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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