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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 944339Generated: October 25, 2026

Water → 4-[2-Cyclopropyl-1-(4-fluoro-phenyl)-1H-imidazol-4-ylethynyl]-2-methyl-pyridine

https://huagongshe.com/reaction/944339

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantTetrahydrofuranHCID 8028—
ReactantTriethylamineHCID 8471—
ReactantTriphenylphosphineHCID 11776—
ReactantTetrabutylammoniumHCID 16028—
ReactantPalladium ChlorideHCID 24290—
ReactantCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
ReactantFluoride IonHCID 28179—
Reactant2-Methyl-4-((trimethylsilyl)ethynyl)pyridineHCID 21985396—
Reactant2-Cyclopropyl-1-(4-fluoro-phenyl)-4-iodo-1H-imidazoleHCID 69120181—
Product4-[2-Cyclopropyl-1-(4-fluoro-phenyl)-1H-imidazol-4-ylethynyl]-2-methyl-pyridineHCID 10041519—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-d4152ed8551a4085929a5eade4a2a747
Source noteValidation data from https://doi.org/10.1039/C8SC04228D