Potassium Cation → 4-[4-(3-Chloro-6-methoxy-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine

HRID 944374Notes

Reaction equation

HRID 944374 reaction equation
[Cl:1][c:2]1[n:3][c:4]([N:15]2[CH:16]([CH3:20])[CH2:17][CH2:18][CH2:19]2)[n:5][c:6](-[c:8]2[cH:9][cH:10][c:11]([F:14])[cH:12][cH:13]2)[cH:7]1.[Cl:21][c:22]1[c:23]([N:30]2[CH2:31][CH:32]([CH3:36])[NH:33][CH2:34][CH2:35]2)[n:24][c:25]([O:28][CH3:29])[cH:26][cH:27]1.[K+:37].[K+:38].[O-:39][C:40]([O-:41])=[O:42]>>[c:2]1([N:33]2[CH:32]([CH3:36])[CH2:31][N:30]([c:23]3[c:22]([Cl:21])[cH:27][cH:26][c:25]([O:28][CH3:29])[n:24]3)[CH2:35][CH2:34]2)[n:3][c:4]([N:15]2[CH:16]([CH3:20])[CH2:17][CH2:18][CH2:19]2)[n:5][c:6](-[c:8]2[cH:9][cH:10][c:11]([F:14])[cH:12][cH:13]2)[cH:7]1

Participants

5

Reactant 4

HCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 121612594-Chloro-6-(4-fluorophenyl)-2-(2-methylpyrrolidin-1-yl)pyrimidineHCID 688242931-(3-Chloro-6-methoxy-2-pyridinyl)-3-methylpiperazine

Product 1

HCID 688239464-[4-(3-Chloro-6-methoxy-pyridin-2-yl)-2-methyl-piperazin-1-yl]-6-(4-fluoro-phenyl)-2-(2-methyl-pyrrolidin-1-yl)-pyrimidine

Sources & evidence

ORD record
ord-1e13c4f24ea64b8297a72f59a46141b0
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

Loading…