Acetone → 2-[5-(2-Acetylaminopyridin-4-yl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-2-ylsulfanyl]-N,N-bis(2-hydroxyethyl)acetamide

HRID 944391Notes

Reaction equation

HRID 944391 reaction equation
[CH3:42][C:43](=[O:44])[CH3:45].[Cl:31][CH2:32][C:33](=[O:34])[N:35]([CH2:36][CH2:37][OH:38])[CH2:39][CH2:40][OH:41].[F:7][c:8]1[cH:9][cH:10][c:11](-[c:14]2[c:15](-[c:21]3[cH:22][c:23]([NH:27][C:28]([CH3:29])=[O:30])[n:24][cH:25][cH:26]3)[n:16]([CH3:20])[c:17](=[S:19])[nH:18]2)[cH:12][cH:13]1.[K+:1].[K+:2].[O-:3][C:4]([O-:5])=[O:6]>>[F:7][c:8]1[cH:9][cH:10][c:11](-[c:14]2[c:15](-[c:21]3[cH:22][c:23]([NH:27][C:28]([CH3:29])=[O:30])[n:24][cH:25][cH:26]3)[n:16]([CH3:20])[c:17]([S:19][CH2:32][C:33](=[O:34])[N:35]([CH2:36][CH2:37][OH:38])[CH2:39][CH2:40][OH:41])[n:18]2)[cH:12][cH:13]1

Participants

6

Reactant 5

HCID 180AcetoneHCID 813Potassium Cation2×HCID 19660Carbonate IonHCID 3505652-chloro-N,N-bis(2-hydroxyethyl)acetamideHCID 11782826N-{4-[5-(4-fluorophenyl)-3-methyl-2-thioxo-2H-imidazol-4-yl]pyridin-2-yl}acetamide

Product 1

HCID 587523312-[5-(2-Acetylaminopyridin-4-yl)-4-(4-fluorophenyl)-1-methyl-1H-imidazol-2-ylsulfanyl]-N,N-bis(2-hydroxyethyl)acetamide

Sources & evidence

ORD record
ord-5930a6692744406baed2627cf23970af
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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