Acetic Acid → tert-Butyl 4-{[5-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-4-yl]methyl}piperazine-1-carboxylate

HRID 944690Notes

Reaction equation

HRID 944690 reaction equation
[C:29](=[O:30])([O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[N:36]1[CH2:37][CH2:38][NH:39][CH2:40][CH2:41]1.[C:42]([OH:43])(=[O:44])[CH3:45].[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([CH:27]=[O:28])[c:11]2[cH:12][cH:13][n:14]([S:18](=[O:19])(=[O:20])[c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[c:15]2[cH:16][cH:17]1.[OH2:46]>>[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[O:8][c:9]1[c:10]([CH2:27][N:39]2[CH2:38][CH2:37][N:36]([C:29](=[O:30])[O:31][C:32]([CH3:33])([CH3:34])[CH3:35])[CH2:41][CH2:40]2)[c:11]2[cH:12][cH:13][n:14]([S:18](=[O:19])(=[O:20])[c:21]3[cH:22][cH:23][cH:24][cH:25][cH:26]3)[c:15]2[cH:16][cH:17]1

Participants

5

Reactant 4

HCID 176Acetic AcidHCID 962WaterHCID 143452tert-Butyl piperazine-1-carboxylateHCID 866182505-(Benzyloxy)-1-(phenylsulfonyl)-1H-indole-4-carbaldehyde

Product 1

HCID 86618249tert-Butyl 4-{[5-(benzyloxy)-1-(phenylsulfonyl)-1H-indol-4-yl]methyl}piperazine-1-carboxylate

Sources & evidence

ORD record
ord-e5013affcfd94cacaaea047ef607462c
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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