Dichloromethane → 3-(4-(Bromomethyl)-3-fluorophenyl)-5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole

HRID 944930Notes

Reaction equation

HRID 944930 reaction equation
[Cl:34][CH2:35][Cl:36].[F:1][c:2]1[c:3]([CH2:28][OH:29])[cH:4][cH:5][c:6](-[c:8]2[n:9][o:10][c:11](-[c:13]3[c:14]([C:24]([F:25])([F:26])[F:27])[c:15](-[c:18]4[cH:19][cH:20][cH:21][cH:22][cH:23]4)[n:16][o:17]3)[n:12]2)[cH:7]1.[P:30]([Br:31])([Br:32])[Br:33]>>[F:1][c:2]1[c:3]([CH2:28][Br:31])[cH:4][cH:5][c:6](-[c:8]2[n:9][o:10][c:11](-[c:13]3[c:14]([C:24]([F:25])([F:26])[F:27])[c:15](-[c:18]4[cH:19][cH:20][cH:21][cH:22][cH:23]4)[n:16][o:17]3)[n:12]2)[cH:7]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 24614Phosphorus tribromideHCID 67457612(2-Fluoro-4-(5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazol-3-yl)phenyl)methanol

Product 1

HCID 674561223-(4-(Bromomethyl)-3-fluorophenyl)-5-(3-phenyl-4-(trifluoromethyl)isoxazol-5-yl)-1,2,4-oxadiazole

Sources & evidence

ORD record
ord-654ffa58f1664cd5af2d6a408a106b93
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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