Potassium Cation → 5-[5-(1-Azetidinylsulfonyl)-2-thienyl]-3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxamide

HRID 945045Notes

Reaction equation

HRID 945045 reaction equation
[Br:30][c:31]1[cH:32][cH:33][c:34]([S:36](=[O:37])(=[O:38])[N:39]2[CH2:40][CH2:41][CH2:42]2)[s:35]1.[CH2:49]1[O:50][CH2:51][CH2:52][O:53][CH2:54]1.[K+:43].[K+:44].[O-:45][C:46]([O-:47])=[O:48].[O:1]=[S:2]1(=[O:29])[CH2:3][CH2:4][CH:5]([c:8]2[cH:9][nH:10][c:11]3[c:12]([C:26](=[O:27])[NH2:28])[cH:13][c:14]([B:17]4[O:18][C:19]([CH3:20])([CH3:21])[C:22]([CH3:23])([CH3:24])[O:25]4)[cH:15][c:16]23)[CH2:6][CH2:7]1.[OH2:55]>>[O:1]=[S:2]1(=[O:29])[CH2:3][CH2:4][CH:5]([c:8]2[cH:9][nH:10][c:11]3[c:12]([C:26](=[O:27])[NH2:28])[cH:13][c:14](-[c:31]4[cH:32][cH:33][c:34]([S:36](=[O:37])(=[O:38])[N:39]5[CH2:40][CH2:41][CH2:42]5)[s:35]4)[cH:15][c:16]23)[CH2:6][CH2:7]1

Participants

7

Reactant 6

HCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 593327113-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indole-7-carboxamideHCID 593327961-[(5-Bromo-2-thienyl)sulfonyl]azetidine

Product 1

HCID 593326995-[5-(1-Azetidinylsulfonyl)-2-thienyl]-3-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-1H-indole-7-carboxamide

Sources & evidence

ORD record
ord-ad8d1aaa243a4ab3acceebe1f0cf7e8b
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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