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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 945330Generated: October 31, 2026

1-Methyl-4,4'-bipiperidine → 2-(4-chloro-3-trifluoromethyl-benzyl)-1-(1'-methyl-[4,4']bipiperidinyl-1-yl)-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butan-1,4-dione

https://huagongshe.com/reaction/945330

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methyl-4,4'-bipiperidineHCID 7183041—
Reactantmethyl 2-(4-chloro-3-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoateHCID 68589951—
Reactant2-(4-chloro-3-trifluoromethyl-benzyl)-4-oxo-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butanoic acidHCID 68592393—
Product2-(4-chloro-3-trifluoromethyl-benzyl)-1-(1'-methyl-[4,4']bipiperidinyl-1-yl)-4-[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidin-1-yl]-butan-1,4-dioneHCID 57848217—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetValidation data from https://doi.org/10.1039/C8SC04228D
ORD IDord-ad8229ba5c594a81bb1af98ce9b6212a
Source noteValidation data from https://doi.org/10.1039/C8SC04228D