Acetonitrile → 9-fluoro-2,3-dihydro3-methyl-10-[3-[(methylamino)methyl]-1-pyrrolidinyl]-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

HRID 945337Notes

Reaction equation

HRID 945337 reaction equation
[CH3:21][NH:22][CH2:23][CH:24]1[CH2:25][NH:26][CH2:27][CH2:28]1.[CH3:29][C:30]#[N:31].[F:1][c:2]1[c:3]([F:20])[c:4]2[c:5]3[n:6]([cH:11][c:12]([C:17](=[O:18])[OH:19])[c:13](=[O:16])[c:14]3[cH:15]1)[CH:7]([CH3:10])[CH2:8][O:9]2>>[F:1][c:2]1[c:3]([N:26]2[CH2:25][CH:24]([CH2:23][NH:22][CH3:21])[CH2:28][CH2:27]2)[c:4]2[c:5]3[n:6]([cH:11][c:12]([C:17](=[O:18])[OH:19])[c:13](=[O:16])[c:14]3[cH:15]1)[CH:7]([CH3:10])[CH2:8][O:9]2

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 5342788,9-Difluoro-3-methyl-6-oxo-2,3-dihydro-6H-1-oxa-3a-aza-phenalene-5-carboxylic acidHCID 13491795N-Methyl-1-(pyrrolidin-3-yl)methanamine

Product 1

HCID 137728389-fluoro-2,3-dihydro3-methyl-10-[3-[(methylamino)methyl]-1-pyrrolidinyl]-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid

Sources & evidence

ORD record
ord-bff909479e784b41836e5a626df15f99
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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