HRID9455

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID16249

2,2-Dimethyl-1,3-dioxane-4,6-dione

C6H8O4

HCID31214

Ethyl orthoformate

C7H16O3

HCID136914

Benzenamine, 4-(phenylmethyl)-

C13H13N

HCID308869

3-Benzylaniline

C13H13N

PRODUCTS

生成物

结构：CC1(C)OC(=O)C(=CNc2cccc(Cc3ccccc3)c2)C(=O)O1

HCID21984288

未命名化合物

结构：CC1(C)OC(=O)C(=CNc2ccc(Cc3ccccc3)cc2)C(=O)O1

HCID21984400

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID887

Methanol

CH4O

PROCEDURE

实验过程

Triethyl orthoformate (10.0 mL, 60.1 mmol), Meldrum's acid (8.2 g, 57 mmol), and either 3-benzyl aniline or 4-benzyl aniline (10.0 g, 54.6 mmol) as indicated in the table below in methanol (303 mL) were combined and treated according to the method described in Part A of Example 1 to provide 5-[(3-benzylphenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (15.5 g) or 5-[(4-benzylphenylamino)methylene]-2,2-dimethyl-[1,3]dioxane-4,6-dione (15.2 g), respectively.

WORKUP

后处理

additiontreated

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1497b3ef15dc4b0aace9e821cdb10a10
来源数据集: uspto-grants-2006_08
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07091214B2
来源说明: uspto-grants-2006_08

反应 SMILES

[CH:1](OCC)(OCC)OCC.[CH3:11][C:12]1([CH3:20])[O:19][C:17](=[O:18])[CH2:16][C:14](=[O:15])[O:13]1.[CH2:21]([C:28]1[CH:29]=[C:30]([CH:32]=[CH:33][CH:34]=1)[NH2:31])[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1.[CH2:35]([C:42]1[CH:48]=[CH:47][C:45]([NH2:46])=[CH:44][CH:43]=1)[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>CO>[CH2:21]([C:28]1[CH:29]=[C:30]([NH:31][CH:1]=[C:16]2[C:17](=[O:18])[O:19][C:12]([CH3:20])([CH3:11])[O:13][C:14]2=[O:15])[CH:32]=[CH:33][CH:34]=1)[C:22]1[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=1.[CH2:35]([C:42]1[CH:43]=[CH:44][C:45]([NH:46][CH:1]=[C:16]2[C:17](=[O:18])[O:19][C:12]([CH3:20])([CH3:11])[O:13][C:14]2=[O:15])=[CH:47][CH:48]=1)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1