5-Methyl-3-phenylisoxazole-4-carbonyl chloride → 4-{4-[3-(Isobutyrylamino)phenyl]-1-piperidinyl}butyl 5-methyl-3-phenyl-4-isoxazolecarboxylate
Reaction equation
[CH3:24][c:25]1[c:26]([C:36](=[O:37])[Cl:38])[c:27](-[c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[n:28][o:29]1.[OH:1][CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([c:12]2[cH:13][c:14]([NH:18][C:19]([CH:20]([CH3:21])[CH3:22])=[O:23])[cH:15][cH:16][cH:17]2)[CH2:10][CH2:11]1>>[O:1]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH2:7][CH2:8][CH:9]([c:12]2[cH:13][c:14]([NH:18][C:19]([CH:20]([CH3:21])[CH3:22])=[O:23])[cH:15][cH:16][cH:17]2)[CH2:10][CH2:11]1)[C:36]([c:26]1[c:25]([CH3:24])[o:29][n:28][c:27]1-[c:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1)=[O:37]Participants
3
Sources & evidence
- ORD record
- ord-560d5d4f00bb45508df22db34d8071d4
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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