2-(Bromomethyl)tetrahydro-2H-pyran → 4'-chloro-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1'H)-one

HRID 945633Notes

Reaction equation

HRID 945633 reaction equation
[Br:23][CH2:24][c:25]1[o:26][c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]1.[Br:34][CH2:35][CH:36]1[CH2:37][CH2:38][CH2:39][CH2:40][O:41]1.[Cl:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[NH:8][C:9](=[O:22])[C:10]21[c:11]2[c:12]([cH:15][c:16]3[c:20]([cH:21]2)[CH2:19][CH2:18][O:17]3)[O:13][CH2:14]1>>[Cl:1][c:2]1[c:3]2[c:4]([cH:5][cH:6][cH:7]1)[N:8]([CH2:24][c:25]1[o:26][c:27]([C:30]([F:31])([F:32])[F:33])[cH:28][cH:29]1)[C:9](=[O:22])[C:10]21[c:11]2[c:12]([cH:15][c:16]3[c:20]([cH:21]2)[CH2:19][CH2:18][O:17]3)[O:13][CH2:14]1

Participants

4

Reactant 3

HCID 1419172-(Bromomethyl)tetrahydro-2H-pyranHCID 27946052-(Bromomethyl)-5-(trifluoromethyl)furanHCID 59352596HCID 59352596, compound

Product 1

HCID 593523654'-chloro-1'-{[5-(trifluoromethyl)furan-2-yl]methyl}-5,6-dihydrospiro[benzo[1,2-b:5,4-b']difuran-3,3'-indol]-2'(1'H)-one

Sources & evidence

ORD record
ord-e566197c53f94b0ebddd9e0b66e92776
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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