Methanol → trans-4-(4-Tert-butoxycarbonyl-2-oxo-piperazin-1-YL)cyclohexanecarboxylic acid

HRID 945639Notes

Reaction equation

HRID 945639 reaction equation
[CH3:1][O:2][C:3](=[O:4])[CH:5]1[CH2:6][CH2:7][CH:8]([N:11]2[C:12](=[O:24])[CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]2)[CH2:9][CH2:10]1.[CH3:27][OH:28].[Na+:26].[OH-:25]>>[O:2]=[C:3]([OH:4])[CH:5]1[CH2:6][CH2:7][CH:8]([N:11]2[C:12](=[O:24])[CH2:13][N:14]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:15][CH2:16]2)[CH2:9][CH2:10]1

Participants

5

Reactant 4

HCID 887MethanolHCID 923Sodium ionHCID 961HydroxideHCID 68452680t-Butyl 4-[trans-4-(methoxycarbonyl)cyclohexyl]-3-oxopiperazine-1-carboxylate

Product 1

HCID 57633483trans-4-(4-Tert-butoxycarbonyl-2-oxo-piperazin-1-YL)cyclohexanecarboxylic acid

Sources & evidence

ORD record
ord-2e40af698c5d4cc39fd63dae6e1f9606
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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