(3-Cyano-5-fluorophenyl)boronic acid → 3-(5,5-Dimethyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl)-5-fluorobenzonitrile

HRID 945709Notes

Reaction equation

HRID 945709 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:15]1)[C:7]([CH3:13])([CH3:14])[O:8][CH2:9][C:10](=[O:12])[NH:11]2.[C:16](#[N:17])[c:18]1[cH:19][c:20]([B:25]([OH:26])[OH:27])[cH:21][c:22]([F:24])[cH:23]1>>[c:2]1(-[c:20]2[cH:19][c:18]([C:16]#[N:17])[cH:23][c:22]([F:24])[cH:21]2)[cH:3][cH:4][c:5]2[c:6]([cH:15]1)[C:7]([CH3:13])([CH3:14])[O:8][CH2:9][C:10](=[O:12])[NH:11]2

Participants

3

Reactant 2

HCID 23435605(3-Cyano-5-fluorophenyl)boronic acidHCID 688658147-bromo-5,5-dimethyl-1,5-dihydro-4,1-benzoxazepin-2(3H)-one

Product 1

HCID 112321363-(5,5-Dimethyl-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-7-yl)-5-fluorobenzonitrile

Sources & evidence

ORD record
ord-8a1fb7f20eca41cbabd659e5e4055893
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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