3-Aminophenol → N4-(6-chloropyridin-3-yl)-5-fluoro-N2-(3-hydroxyphenyl)-2,4-pyrimidinediamine
Reaction equation
[Cl:9][c:10]1[n:11][cH:12][c:13]([F:24])[c:14]([NH:16][c:17]2[cH:18][n:19][c:20]([Cl:23])[cH:21][cH:22]2)[n:15]1.[OH:1][c:2]1[cH:3][c:4]([NH2:5])[cH:6][cH:7][cH:8]1>>[OH:1][c:2]1[cH:3][c:4]([NH:5][c:10]2[n:11][cH:12][c:13]([F:24])[c:14]([NH:16][c:17]3[cH:18][n:19][c:20]([Cl:23])[cH:21][cH:22]3)[n:15]2)[cH:6][cH:7][cH:8]1Participants
3
Sources & evidence
- ORD record
- ord-6f22b522dc464ad79310f6003d057979
- Source dataset
- Validation data from https://doi.org/10.1039/C8SC04228D
Reaction notes
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