Isobutylamine → N-[2-Fluoro-3-(2-(1-methylethyl)-5-{2-[(2-methylpropyl)amino]-4-pyrimidinyl}-1,3-thiazol-4-yl)phenyl]-2-methylbenzenesulfonamide

HRID 94644Notes

Reaction equation

HRID 94644 reaction equation
[CH2:34]([CH:35]([CH3:36])[CH3:37])[NH2:38].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[c:17]([F:33])[c:18]([NH:22][S:23](=[O:24])(=[O:25])[c:26]4[c:27]([CH3:32])[cH:28][cH:29][cH:30][cH:31]4)[cH:19][cH:20][cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1>>[c:2]1([NH:38][CH2:34][CH:35]([CH3:36])[CH3:37])[n:3][cH:4][cH:5][c:6](-[c:8]2[c:9](-[c:16]3[c:17]([F:33])[c:18]([NH:22][S:23](=[O:24])(=[O:25])[c:26]4[c:27]([CH3:32])[cH:28][cH:29][cH:30][cH:31]4)[cH:19][cH:20][cH:21]3)[n:10][c:11]([CH:13]([CH3:14])[CH3:15])[s:12]2)[n:7]1

Participants

3

Reactant 2

HCID 6558IsobutylamineHCID 57989645N-{3-[5-(2-Chloro-4-pyrimidinyl)-2-(1-methylethyl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2-methylbenzenesulfonamide

Product 1

HCID 57989972N-[2-Fluoro-3-(2-(1-methylethyl)-5-{2-[(2-methylpropyl)amino]-4-pyrimidinyl}-1,3-thiazol-4-yl)phenyl]-2-methylbenzenesulfonamide

Sources & evidence

ORD record
ord-01dadd68bdd44f46bb71d4698cc124ec
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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