Acetonitrile → 4-(4-Acetyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester

HRID 946700Notes

Reaction equation

HRID 946700 reaction equation
[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][NH:11][CH2:12][CH2:13]1.[CH3:14][S:15]([c:16]1[cH:17][cH:18][c:19]([C:20](=[O:21])[CH3:22])[c:23]([CH3:24])[cH:25]1)(=[O:26])=[O:27].[CH3:39][C:40]#[N:41].[Cl:28][CH2:29][c:30]1[cH:31][cH:32][c:33]([C:36]([CH3:37])=[O:38])[cH:34][cH:35]1>>[C:1](=[O:2])([O:3][C:4]([CH3:5])([CH3:6])[CH3:7])[N:8]1[CH2:9][CH2:10][N:11]([CH2:29][c:30]2[cH:31][cH:32][c:33]([C:36]([CH3:37])=[O:38])[cH:34][cH:35]2)[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6342AcetonitrileHCID 143452tert-Butyl piperazine-1-carboxylateHCID 124348461-(4-(Chloromethyl)phenyl)ethan-1-oneHCID 670496691-(2-Methyl-4-methylsulfonylphenyl)ethanone

Product 1

HCID 582083844-(4-Acetyl-benzyl)-piperazine-1-carboxylic acid tert-butyl ester

Sources & evidence

ORD record
ord-7ae1d2c7c3344fb7941ea3e131b816e4
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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