3-(Trifluoromethyl)aniline → ethyl 1-[(4-{[3-(trifluoromethyl)phenyl]carbamoyl}-1,3-thiazol-2-yl)methyl]-1H-pyrazole-4-carboxylate

HRID 946940Notes

Reaction equation

HRID 946940 reaction equation
[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][n:9]([CH2:11][c:12]2[s:13][cH:14][c:15]([C:17](=[O:18])[OH:19])[n:16]2)[cH:10]1.[F:20][C:21]([c:22]1[cH:23][c:24]([NH2:25])[cH:26][cH:27][cH:28]1)([F:29])[F:30]>>[CH2:1]([CH3:2])[O:3][C:4](=[O:5])[c:6]1[cH:7][n:8][n:9]([CH2:11][c:12]2[s:13][cH:14][c:15]([C:17](=[O:19])[NH:25][c:24]3[cH:23][c:22]([C:21]([F:20])([F:29])[F:30])[cH:28][cH:27][cH:26]3)[n:16]2)[cH:10]1

Participants

3

Reactant 2

HCID 73753-(Trifluoromethyl)anilineHCID 669392482-{[4-(ethoxycarbonyl)-1H-pyrazol-1-yl]methyl}-1,3-thiazole-4-carboxylic acid

Product 1

HCID 66938976ethyl 1-[(4-{[3-(trifluoromethyl)phenyl]carbamoyl}-1,3-thiazol-2-yl)methyl]-1H-pyrazole-4-carboxylate

Sources & evidence

ORD record
ord-6430ec48ba9d4dde869158d828ea56a8
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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