3-Pyridinylboronic acid → [3-Methyl-5-pyridin-3-yl-2-(4-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

HRID 946981Notes

Reaction equation

HRID 946981 reaction equation
[I:1][c:2]1[c:3]([C:18](=[O:19])[N:20]2[CH2:21][CH2:22][CH:23]([N:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[CH2:24][CH2:25]2)[n:4]([CH3:17])[c:5](-[c:7]2[cH:8][cH:9][c:10]([C:13]([F:14])([F:15])[F:16])[cH:11][cH:12]2)[n:6]1.[n:31]1[cH:32][c:33]([B:37]([OH:38])[OH:39])[cH:34][cH:35][cH:36]1>>[c:2]1(-[c:33]2[cH:32][n:31][cH:36][cH:35][cH:34]2)[c:3]([C:18](=[O:19])[N:20]2[CH2:21][CH2:22][CH:23]([N:26]3[CH2:27][CH2:28][CH2:29][CH2:30]3)[CH2:24][CH2:25]2)[n:4]([CH3:17])[c:5](-[c:7]2[cH:8][cH:9][c:10]([C:13]([F:14])([F:15])[F:16])[cH:11][cH:12]2)[n:6]1

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 57541088[5-iodo-3-methyl-2-(4-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Product 1

HCID 57541084[3-Methyl-5-pyridin-3-yl-2-(4-trifluoromethyl-phenyl)-3H-imidazol-4-yl]-(4-pyrrolidin-1-yl-piperidin-1-yl)-methanone

Sources & evidence

ORD record
ord-8c1b613dbd2542eaa25053cdb1bb78fa
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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