Boron tribromide → 3-(4-Bromocyclohexyl)-1-[[2,6-dichloro-4-(4-fluorophenyl)phenyl]methyl]pyrrolidin-2-one

HRID 947072Notes

Reaction equation

HRID 947072 reaction equation
[B:31]([Br:32])([Br:33])[Br:34].[Cl:1][c:2]1[cH:3][c:4](-[c:24]2[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]2)[cH:5][c:6]([Cl:23])[c:7]1[CH2:8][N:9]1[C:10](=[O:22])[CH:11]([CH:14]2[CH2:15][CH2:16][CH:17]([O:20][CH3:21])[CH2:18][CH2:19]2)[CH2:12][CH2:13]1>>[Cl:1][c:2]1[cH:3][c:4](-[c:24]2[cH:25][cH:26][c:27]([F:30])[cH:28][cH:29]2)[cH:5][c:6]([Cl:23])[c:7]1[CH2:8][N:9]1[C:10](=[O:22])[CH:11]([CH:14]2[CH2:15][CH2:16][CH:17]([Br:32])[CH2:18][CH2:19]2)[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 25134Boron tribromideHCID 673562951-(3,5-Dichloro-4'-fluoro-biphenyl-4-ylmethyl)-3-(4-methoxy-cyclohexyl)-pyrrolidin-2-one

Product 1

HCID 673556323-(4-Bromocyclohexyl)-1-[[2,6-dichloro-4-(4-fluorophenyl)phenyl]methyl]pyrrolidin-2-one

Sources & evidence

ORD record
ord-3d9a09ef258540caaac77797c59be25c
Source dataset
Validation data from https://doi.org/10.1039/C8SC04228D

Reaction notes

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